LCModel是一套被廣泛使用的磁振頻譜分析軟體

LCModel包用於體內質子MR spec tra的自動定量。LCMgui是用於運行LCModel的圖形用戶界面，具有更多的便利性和更少的知識。LCMgui僅免費提供與LCModel一起使用。

LCMgui圖形用戶界面

正常用法是將時域數據作為簡單文本文件提供給LCModel。可能的替代方案是LCMgui圖形用戶界面：

   •可自由使用LCModel。

   •通常僅通過鼠標點擊簡化使用，分兩步：

1 使用文件選擇器選擇數據

2 在控制窗口中啟動LCModel（可選地檢查和修改任何設置）

   •目前針對以下單體素數據：

      。 Bruker ParaVision的fid文件（如果需要，可以使用Bruker's轉換為模擬模式convdta）。

      。 GE 5.x探測原始P文件和光譜G文件。

      。 GE Probe原始P文件，包括（新） Signa 20 P文件。也適用於具有多通道（相控陣）數據的P文件。

      。 日立數據：日立軟件的一部分; 無需單獨購買。

      。 飛利浦SDAT和SPAR文件。

      。 Picker（後來的Marconi，現在的飛利浦）DUMP文件。

      。 從syngo PC控制台轉移的Siemens * rda文件和來自（舊）Numaris-3 Unix控制台的Siemens原始文件。

      。 東芝rawData文件和版本7.xx（及更高版本）DICOM文件。

      。 瓦里安fid文件。

      。 使用您自己的轉換腳本的其他數據類型。

   •目前針對以下MRSI數據

      。布魯克（模擬模式），飛利浦，西門子和東芝數據，包括交互式顯示，選擇和分析完整的2D切片或矩形子集。（LCModel手冊第3.6節中的說明。）

      。使用您自己的轉換腳本的其他數據類型;

      。為GE MRSI（和單體素）的數據，瑪麗麥克萊恩的LCModel接口[MA麥克萊恩等人，在勵磁立信地中海 44， 401（2000）]被集成到GE的SAGE研究版本（來自SAGE Dev2002.1）。

特徵：

   •全自動，非交互式，獨立於操作員：時域數據輸入，單頁摘要輸出。

   •完全開發，超過17年，從各種掃描儀和超過500個站點的場強分析光譜。

Application:

• Automatic quantification of in vivo proton MR spectra.


• Some early user applications of LCModel can be seen in the sample publications list .

News:

LCModel Version 6.3 (free upgrade for current LCModel sites):

• Estimation of GABA with MEGA-PRESS.
• Improved estimation of weaker metabolites, especially glutamine.
• Improved analyses of muscle, lipid, breast and liver spectra.

Past News:

LCModel Version 6.2. While the main application remains

, options have been added for more primitive spectra:

• Mainly water & lipids, as in fat and bone marrow.
• Water & lipids plus possibly choline, as inbreast and liver.
• LCModel Version 6.1 with new options, including analysis of muscle spectra, particularly for IMCL.
• A Linux version for PCs (with Intel or AMD processors) is now available. It is much faster than UNIX, with an excellent hardware performance/price ratio, particularly interesting for MRSI.
• In Japan, you obtain LCModel (and support) directly from the exclusive LCModel distributor for Japan, L.A. Systems, http://www.las.jp.
• Major new LCModel Version 6 with many new features, including:
• Estimates of macromolecule and lipid contributions in normals and in pathologies (e.g., tumors) with strong lipid signals and without strong lipid signals.
• Analyses of full 2D slices or rectangular 2D subsets of 2D or 3D MRSI data sets.

Features:

• Fully automatic, non-interactive, operator-independent: time-domain data input, one-page summary output.
• Fully developed, over 26 years, with spectra analyzed from a wide variety of scanners and field strengths at more than 1000 sites.

Download, Install & Test:

• You can freely download the complete LCMgui/LCModel package for your Linux PC. (The two commands needed for installation and the run with the test data are also specified.) You can also test the preparation and input of your own data to LCModel.
• You can fully enable your LCModel package to analyze all data (not just the test data) with a license.

Methods are described in:

• Stephen Provencher: Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30, 672 (1993).


• User's Manual (you can always get the latest version here).

LCMgui Graphical User Interface

The normal usage is to supply the time-domain data as a simple text file to LCModel. A possible alternative is the LCMgui graphical user interface:

• Freely available for use with LCModel.
• Simplified usage, often only with mouse clicks, in two steps:
  1. Select the data with the File Selector ;
  2. Start LCModel (optionally checking and modifying any settings) in the Control Window.
• Currently for the following single-voxel data:
  • Bruker fid files.
  • GE 5.x Probe raw P-files and spectrum G-files.
  • GE Probe raw P-files. Also for P-files with multi-channel (phased-array) data.
  • Hitachi data: part of the Hitachi software; no need to purchase separately.
  • Philips SDAT/SPAR pairs and enhanced DICOM files.
  • Picker (later Marconi, now Philips) DUMP files.
  • Siemens *rda files transferred from the syngo PC console and Siemens raw files from the (old) Numaris-3 Unix console.
  • Toshiba rawData files and Version 7.xx (and later) DICOM files.
  • Varian/Agilent fid files.
  • Other data types using your own conversion script.
• Currently for the following MRSI data:
  • Philips, Siemens & Toshiba single-channel data, including interactive display, selection and analysis of full 2D slices or rectangular subsets. (Instructions in Sections 3.2 & 3.7 of the LCModel Manual .)
  • Other data types using your own conversion script;
  • For GE MRSI (and single-voxel) data, Mary McLean's SAGE/LCModel interface [MA McLean et al, Magn Reson Med 44, 401 (2000)] is integrated into GE's SAGE Research version (from SAGE Dev2002.1).
  •